The principles are:
🔹 Every step of clinical evidence generation will be further guided by the patient voice; 
🔹 Existing data and knowledge will further inform generation of clinical evidence; 
🔹 Study design will be driven by research questions; 
🔹 Clinical trials will be more efficient and impactful; 
🔹 Real-world evidence will be enabled and its value fully established; 
🔹 Trust will be built through transparency.
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