06 Mart 2016
Akademik Tıp Kurumlarındaki klinik araştırmaların yayınlanması..
Yapılan çalışmaların yayınlanması açısından sonuçlar pek yüz güldürücü değil.
Publication and reporting of clinical trial results: cross sectional
analysis across academic medical centers
Ruijun Chen, Nihar R Desai, Joseph S Ross, Weiwei Zhang, Katherine H Chau, Brian
Wayda, Karthik Murugiah, Daniel Y Lu, Amit Mittal, Harlan M Krumholz
To determine rates of publication and reporting of
results within two years for all completed clinical trials
registered in ClinicalTrials.gov across leading
academic medical centers in the United States.
Cross sectional analysis.
Academic medical centers in the United States.
Academic medical centers with 40 or more completed
interventional trials registered on ClinicalTrials.gov.
Using the Aggregate Analysis of ClinicalTrials.gov
database and manual review, we identi ed all
interventional clinical trials registered on ClinicalTrials.
gov with a primary completion date between October
2007 and September 2010 and with a lead investigator
a liated with an academic medical centre.
Main Outcome Measures
The proportion of trials that disseminated results,
de ned as publication or reporting of results on
ClinicalTrials.gov, overall and within 24 months of
We identified 4347 interventional clinical trials across
51 academic medical centers. Among the trials, 1005
(23%) enrolled more than 100 patients, 1216 (28%)
were double blind, and 2169 (50%) were phase II
through IV. Overall, academic medical centers disseminated results for 2892 (66%) trials, with 1560
(35.9%) achieving this within 24 months of study
completion. The proportion of clinical trials with
results disseminated within 24 months of study
completion ranged from 16.2% (6/37) to 55.3%
(57/103) across academic medical centers. The
proportion of clinical trials published within 24 months
of study completion ranged from 10.8% (4/37) to
40.3% (31/77) across academic medical centers,
whereas results reporting on ClinicalTrials.gov ranged
from 1.6% (2/122) to 40.7% (72/177).
Despite the ethical mandate and expressed values and
mission of academic institutions, there is poor
performance and noticeable variation in the
dissemination of clinical trial results across leading
academic medical centers.